amiloride vs hydrochlorthiazide therapy in children with nephrotic syndrome: a clinical trial

نویسندگان

soheila mahdavinia iran university of medical sciences, tehran, iran

hasan otukesh iran university of medical sciences, tehran, iran

rozita hoseini iran university of medical sciences, tehran, iran

mehrdad shheikhvatan iran university of medical sciences, tehran, iran

چکیده

background and objective: to assess the effectiveness and safety of oral amiloride for the treatment of edema in pediatric patients with idiopathic nephrotic syndrome. methods: a randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. the mean age was 4.3±0.7 years old. after a 2 week washout of diuretic therapy, nephrotic children with edema were randomized into two groups receiving amiloride vs hydrochlorthiazide. the effect of diuretics was assessed by the amount of weight reduction and the measurement of urinary fractional excretion of sodium during the first three days of diuretic therapy. the primary end point was the decrease in body weight. findings: of 34 patients enrolled for this trial, 17 patients were in amiloride group and 17 patients in hydrochlorthiazide group. the mean weight loss during the first three days of diuretic therapy was 1.3±0.65 kg in amiloride group and 1.19±0.4 kg in hydrochlorthiazide group (pv=0.55). the mean of maximum urinary fractional excretion of sodium during the first three days of diuretic therapy was 2.1±0.65% in amiloride group and 1.8±1% in hydrochlorthiazide group. conclusion: there was not any difference between amiloride and hydrochlorthiazide medications in reducing weight and increasing urinary fractional excretion of sodium in children with nephrotic syndrome.

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Amiloride vs hydrochlorthiazide therapy in children with nephrotic syndrome: A clinical trial

Background and Objective: To assess the effectiveness and safety of oral amiloride for the treatment of edema in pediatric patients with idiopathic nephrotic syndrome. Methods: A randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. The mean age was 4.3±0.7 years old. After a 2 week washout of diuretic therapy, nephrotic children with edema were randomized into two gr...

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